Prep Ingredients: Grate all the cheeses into a large bowl and toss to combine. Reserve about 2 cups of the grated cheese for topping. In a separate bowl, combine the cubed chicken, buttermilk, and 2 tbsp hot sauce. In a shallow dish, whisk together the flour, panko, garlic powder, chili powder, paprika, and a generous pinch of salt and pepper.
Make the Cheese Sauce: In a large pot or Dutch oven, melt the butter over medium heat. Add the chili powder, paprika, and garlic powder, stirring for about 30 seconds until fragrant. Pour in the evaporated milk, heavy cream, and milk, and stir. Heat until the liquid is warm, but do not let it boil. Remove the pot from the heat. Add the non-reserved grated cheeses a handful at a time, stirring until melted before adding the next. Season with salt to taste.
Cook Pasta & Assemble: Bring a large pot of salted water to a boil and cook the macaroni until al dente. Drain well. Pour the cheese sauce over the pasta and stir. Spread half of the mac and cheese into a 9x13 inch baking dish. Sprinkle with 1 cup of the reserved cheese. Top with the remaining mac and cheese, then sprinkle the final cup of reserved cheese over the top. Bake in a preheated 350°F (175°C) oven for 20-25 minutes, until bubbly and golden.
Dredge the Chicken: While the mac and cheese bakes, prepare the chicken. Remove a chicken cube from the buttermilk, letting excess drip off. Dredge it in the flour mixture. Dip it back into the buttermilk, then dredge it once more in the flour, pressing to create a thick coating. Place the coated chicken on a wire rack and repeat.
Fry and Sauce the Chicken: Heat neutral oil in a heavy-bottomed pot to 350°F (175°C). Fry the chicken in batches for 4-6 minutes, until golden brown and cooked through. Transfer to a clean wire rack. While frying, whisk together all the honey BBQ sauce ingredients in a large bowl. Toss the hot, cooked chicken in the BBQ sauce until coated.
Final Assembly & Serving: Let the mac and cheese rest for 5 minutes. Pile the saucy BBQ chicken on top. Garnish with chopped fresh parsley, if desired, and serve immediately.